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Alkermes to trim 150 jobs
Alkermes Inc. said yesterday it plans to cut about 150 jobs, or 18 percent of the Cambridge biotech's workforce,[url=http://nikefreetilbud.hcslnet.com]nike free run[/url], this week and shut down its Chelsea manufacturing plant after a partner decided to halt development of an inhalable form of insulin for diabetics.
The move comes two weeks after Alkermes's partner, Eli Lilly Co., pulled the plug on the Air Insulin project, making it the latest in a string of companies to give up plans to market an inhalable form of insulin as an alternative to injections. In recent months, two other drug makers Pfizer Inc. and Novo Nordisk A/S of Denmark have also scrapped work on their versions of inhalable insulin.
"It seems like the market environment is not optimal to be going forward with candidates for pulmonary insulin," said Alkermes spokeswoman Rebecca Peterson. Instead, she said, the company will try to use the technology to develop inhalable treatments for other diseases such as chronic obstructive pulmonary disease.
Eli Lilly's decision was a disappointment for Al kermes because some thought the product had the potential to generate billions of dollars in annual sales. In the United States alone, there are an estimated 21 million diabetics, many of whom need to take insulin regularly to regulate their blood sugar levels. Eli Lilly and Alkermes were hoping to ask the Food and Drug Administration for approval to start marketing the product in 2009.
But after Pfizer spent $3 billion developing its own version of the product, the New York pharmaceutical giant found many doctors and patients were reluctant to switch from injectable insulin. Also, some doctors worried about the potential longterm health effects of insulin on the lungs.
Alkermes said it expects to take a restructuring charge of $5 million to $10 million, plus an impairment charge of up to $15 million, associated with the job cuts and plant closure. The company said laidoff workers will be eligible for severance pay and other benefits.
Peterson said Alkermes received economic incentives from the state and the city of Chelsea to build the plant, which opened in 2003, but is not obligated to return any money.
Kofi Jones, a spokeswoman for the Massachusetts Executive Office of Housing and Economic Development, said Alkermes received a reduction in its corporate excise taxes in exchange for its investment a standard tax break available to companies that expand in Massachusetts and a discount on its property taxes from the city. Jones was not sure how much money the company saved in taxes because of the incentives.
Regardless of the inhalable insulin failure, Alkermes executives said, the company remains in sound financial shape with more than $500 million in cash.
Alkermes also has revenue from two products on the market, Risperdal Consta (an injectable form of Johnson Johnson's oral schizophrenia drug) and Vivitrol (a monthly injection to treat alcoholism that is marketed by Cephalon Inc.). It also has a pipeline of medications in development.
The company recorded $178 million in revenue for the nine months ended Dec. 31, up 2 percent from the same period a year ago, with a $15 million operating profit.
After the cuts, Alkermes will have 665 employees, including 260 in Massachusetts. Alkermes shares fell 3 cents to close at $10.82. It has a stock market value of more than $1 billion, making it one of the larger biotechs based in Massachusetts.

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May 6,[link widoczny dla zalogowanych], 2012 afternoon 15 when make,[link widoczny dla zalogowanych], during the defendant Dengmou accompanied her friend to sign the contract in a real estate company in Nanchang City,[link widoczny dla zalogowanych], because of the purchase matters and the victim Wang Mou and triggered a dispute, the defendant Dengmou punch the victim Wang Mou left wounded, to the left of orbital wall fracture. The Nanchang City Police Department forensic identification, the victim Wang Mou damage degree for minor injuries to Serie A,[link widoczny dla zalogowanych], then the victim Wang Mou alarm, security personnel rushed to the scene to the defendant Dengmou summoned verbally to the public security organ for investigation.
author unit: Jiangxi Nanchang City East Lake District People's court
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the first instance court think, the defendant Deng deliberately hurt others body, causing others injured grade A,[link widoczny dla zalogowanych], his behavior constituted the crime of intentional injury. The case for civil conflicts triggered,[link widoczny dla zalogowanych], and the defendant was arrested after Deng can truthfully confessed his crime and voluntary confession in court,[link widoczny dla zalogowanych], he may be given a lighter punishment. According to the defendant's criminal facts,[link widoczny dla zalogowanych], nature, circumstances of sentencing and the degree of harm to society, then the above verdict.
to accompany a friend to sign a contract, but with people fight and others injured. In August 10, 2012, Jiangxi Province,[link widoczny dla zalogowanych], East Lake City,[link widoczny dla zalogowanych], Nanchang District People's court hearing the case. Sentenced to the defendant Dengmou committed the crime of intentional injury,[link widoczny dla zalogowanych], sentenced to one year in prison.
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May 23rd, Dengzhou Ji Tan Zhen Beibei kindergarten in the process with the school bus in the morning preschool, a 3 year old Lee's forgotten school car, afternoon sent students home, only to find that the infant choking in the car. After the hospital rescue invalid death.

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Press the bell
Haikou Meilan District coast line of 118 kilometers, near the beach area of 73400 mu,[link widoczny dla zalogowanych], is a large area of Haikou city fishery,[link widoczny dla zalogowanych], fishery economy has become one of the pillar industry of rural economics Meilan district. Reporter was informed yesterday, Meilan District will use the rich marine resources,[link widoczny dla zalogowanych], vigorously.
"Meilan District at present fisheries production limited to shore aquaculture,[link widoczny dla zalogowanych], mostly coastal economy,[link widoczny dla zalogowanych], to realize the strong ocean area target,[link widoczny dla zalogowanych], must from coast to coast into the deep sea,[link widoczny dla zalogowanych], from the economy to realize marine industry, fishery industry upgrading." Meilan District Officer Lin Gang said, in order to fishery development Meilan District, promote the coast economic leap to marine industry, Meilan District is to benefit from deep sea cage industry, driving the Deepwater fisheries base construction.
it is understood, Meilan District is currently stepping up the construction of Haikou deep sea cage industry base. The base is located in Fengzhen City, the new act tower Xi Jiao,[link widoczny dla zalogowanych], using sea area of 2000 mu,[link widoczny dla zalogowanych], 50 mu of land to land supporting,[link widoczny dla zalogowanych], put on the deep-water cage 600,[link widoczny dla zalogowanych], projects with a total investment of about 95000000 yuan. The project has been in 2012 as "Duanpingkuai" Meilan District, one of the project, has completed the first phase of the land lease and the right location and 448 acres of waters,[link widoczny dla zalogowanych], is expected by the end of the construction investment of 30000000 yuan, on the cage 200, the scale of farming grouper, cobia and Trachinotus, and other fish species.
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Shanghai City, jointly with the Municipal Commission of Commerce, the district actively implement measures, efforts to defuse the cabbage and other vegetables and seasonal varieties structural slow-moving problem.

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The
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"implementation of the opinions" provisions, documents of construction project environmental impact environmental protection bureau is responsible for the approval of the assessment includes: Provincial Environmental Protection Department commissioned by the municipal environmental protection department for examination and approval of the construction project; City Hall investment department in charge of examination and approval,[link widoczny dla zalogowanych], approval, filing of the construction project; which may have a great impact on the ecological environment construction projects, including chemical, synthetic leather and artificial leather, paper making, shipbuilding, brewing, pesticide, electroplating, disposal of medical waste, monosodium glutamate, citric acid, enzyme preparation, yeast,[link widoczny dla zalogowanych], livestock and poultry breeding, mineral exploration, in addition to the ordinary building sand stone outside of all non metal ore mining, ore dressing, and the cross county (city, district) administrative region of the construction project. Documents of construction project environmental impact county environmental protection department in charge of examination and approval evaluation include: Municipal Environmental Protection Bureau commissioned by the competent administrative department of environmental protection approval of the project; and the county (city, district) within the administrative region of a construction project examination and approval shall, except by the higher administrative department of environmental protection.
relates to the EIA approval authority projects include: the decentralized registration form the preparation of environmental impact to be City Hall investment department in charge of examination and approval, approval,[link widoczny dla zalogowanych], filing of the project, social undertakings and service industry,[link widoczny dla zalogowanych], agriculture and water conservancy of all,[link widoczny dla zalogowanych], machinery and electronics,[link widoczny dla zalogowanych], city infrastructure such as the eleven major categories of part of the project will be commissioned; the preparation of environmental impact for approval by the districts of the municipal environmental protection department management regulations of the office of the provincial environmental protection grade examination and approval of the registration form, and non-metallic mineral mining, geological prospecting, electric power and other five categories in the part of the project.
To share:
newspaper news (reporter Luo Peixin trainee reporter Liu Mingming correspondent Zheng Wenwen) recently, the reporter learned from the Municipal Environmental Protection Bureau, "Zhangzhou city construction project environmental impact assessment document classification approval implementation opinions" has recently been published, the decision of the EIA classification new approval system, decentralization and principal part of EIA approval authority to the county environmental protection department.
at the same time, in order to shorten the time of examination and approval, the overall situation better service development, the next step,[link widoczny dla zalogowanych], the City Environmental Protection Bureau will be presented in accordance with the municipal Party committee City Hall "examination and approval,[link widoczny dla zalogowanych], the approval process for at least the shortest, service the highest efficiency" of the objectives and requirements,[link widoczny dla zalogowanych], and strengthen the change cadre style,[link widoczny dla zalogowanych], the key problem to strengthen supervision and coordination, and strive to the realization of emission reduction work guarantees four struggles three goals. In addition,[link widoczny dla zalogowanych], according to "do it right away, things do not stay overnight" requirements, responsibility, pragmatic and efficient performance of good job, keep the spirits and high work enthusiasm, to serve the development of Zhangzhou industry.
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At present, the project has been the City Planning Commission will pass, has completed the project planning and design, land property, land and other related work is being submitted for approval.